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Improved PET Scans To Detect Early Alzheimer’s Disease

By admin | August 8, 2008

Researchers at Avid Radiopharmaceuticals in Philadelphia, Pennsylvania presented reported their development of a novel 18F-labeled PET imaging agent that may make PET scans a routine diagnostic tool for early Alzheimer’s disease.

Michael J. Pontecorvo, PhD and colleagues reported their findings at last weeks ICAD 2008 meeting in Chicago, Illinois.

PET scans to date have not been widely used in the study of the abnormal acculumation of brain amyloid characteristic in Alzheimers because of the short half-life of the first radioactive tracer 11C-PIB (aka Pittsburgh Compound B). This prompted researchers to try other longer-acting radiotracers, such as flourine based tracers, to detect the abnormal build-ups.

In their study, Pontecorvo injected different 18F compounds into patients with Alzheimer’s disease and healthy controls. Disease-carrying patients showed retention of the amyloid binding tracer in brain areas  minutes after injection. Healthy patients showed rapid clearance from the brain. One tracer used, 18F-AV-45 was noted to have particularly rapid uptake and constant levels in the brain up t0 90 minutes post-injection.

Copyright 2008 Medgizmo.com

Topics: Alzheimer's Disease, Imaging, Neurology |

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