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Real-time Detection of Staph Aureus Using Novel Optical Microscope and Lytic Phage Probes

By admin | August 17, 2008

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Researchers at Auburn University have developed a system of detecting Staphylococcus Aureus using an optical microscope in real-time. Led by Vitaly Vodyanoy, PhD, their report appears in the September 15 issue of Biosensors and Bioelectronics.

Staphylococcus Aureus and in particular the strain (MRSA) that is now drug resistant to methicillin, the antibiotic that was previously used to treat it, is a dangerous human pathogen. Timely diagnosis is key to effective treatment.

Current diagnostic methods involve culturing and growing the bacteria in a laboratory setting. Definitive diagnosis can take up to 72 hours. The test developed at Auburn can be run in minutes on a real-time basis.

Researchers used biorecognition phage monolayers in conjunction with the Langmuir-Blodgett technique to bind to MRSA cultures. The cultures were placed on a previously prepared glass slide and then viewed under an optical light microscope system developed by CytoViva, Inc.

The researchers reported near instantaneous and selective binding for the MRSA and virutally no bind with other non-Staphylococcus species such as Salmonella enterica and Bacillus subtilis.

The next step in developing this technology, according to Dr. Vitaly Vodyanoy, is to use a probe to differentiate MRSA from non-MRSA specimens and to apply this technique to human specimens to test sensitivity and specificity.

Copyright 2008 Medgizmo.com

Topics: Infectious Diseases |

One Response to “Real-time Detection of Staph Aureus Using Novel Optical Microscope and Lytic Phage Probes”

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